anti-TNBC agent-6

CAS: F: C28H18F6N3O2PPt- W: 768.51

anti-TNBC agent-6 (compound pt-3) is a potent anti-TNBC agent. anti-TNBC agent-6 shows cytotoxic activity. anti-TNBC age

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Bioactivity	anti-TNBC agent-6 (compound pt-3) is a potent anti-TNBC agent. anti-TNBC agent-6 shows cytotoxic activity. anti-TNBC agent-6 induces autophagy and ferroptosis. anti-TNBC agent-6 enhances intracellular ROS accumulatio. anti-TNBC agent-6 shows anti tumor activity and has the potential for the research of breast cancer[1].
Invitro	anti-TNBC agent-6 (compound pt-3) (48 h) 对 MDA-MB-231、MCF-7、B16-F10、SK-OV-3、WI-38 细胞具有细胞毒性[1].anti-TNBC agent-6 (2 µM; 0, 12, 24, 36, 48 h) 在 MDA-MB-231 细胞中以时间依赖性方式增加 Beclin-1、LC3-II 的表达来诱导自噬 [1].anti-TNBC agent-6 (2 µM; 0, 12, 24, 36, 48 h) 以时间依赖性方式降低 GPX4 的表达来诱导铁死亡[1]。anti-TNBC agent-6 (1, 2 µM) 以剂量依赖性方式增加 MDA-MB-231 细胞中的 MDA 含量[1]。anti-TNBC agent-6 (2 µM) 可增强细胞内 ROS 积累并增加细胞内的不稳定铁池 (LIP)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> anti-TNBC agent-6 相关抗体: Cell Cytotoxicity Assay[1] Cell Line:
In Vivo	anti-TNBC agent-6 (10 mg/kg; i.p.; on days 0, 3, 6, 9, 12, 15, and 18) 在 MDA-MB-231 异种移植模型中显示出抗肿瘤活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
Formula	C28H18F6N3O2PPt-
Molar Mass	768.51
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wang FY, et al. Cycloplatinated (II) Complex Based on Isoquinoline Alkaloid Elicits Ferritinophagy-Dependent Ferroptosis in Triple-Negative Breast Cancer Cells. J Med Chem. 2024 Mar 25.

N-Acetyl-Leukotriene E4