| Bioactivity | aTAG 4531 (CFT-4531) is a potent, selective, and onmechanism tool degrader of MTH1 with DC50 value of 0.28 nM and Ki value of 1.8 nM. degradation activity is due to the intricate formation of the ternary complex between the MTH1 aTAG, CRBN E3 ligase, and aTAG tool degrader [1]. |
| Name | aTAG 4531 |
| CAS | 2412985-00-1 |
| Formula | C46H39F2N9O7 |
| Molar Mass | 867.85 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Veits G K, et al. Development of an AchillesTAG degradation system and its application to control CAR-T activity [J]. Current Research in Chemical Biology, 2021, 1: 100010. |
aTAG 4531
CAS: 2412985-00-1 F: C46H39F2N9O7 W: 867.85
aTAG 4531 (CFT-4531) is a potent, selective, and onmechanism tool degrader of MTH1 with DC50 value of 0.28 nM and Ki val
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