| Bioactivity | Zinc Protoporphyrin-d2,15N2 is 15N and deuterated labeled Zinc Protoporphyrin (HY-101193). Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2[1]. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration[2]. Zinc Protoporphyrin has anti-cancer activity[3]. |
| Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。Zinc Protoporphyrin (Zn (II)-protoporphyrin IX；5 μM；72 hours) 导致晚期凋亡和坏死细胞的比例从对照组的 10.9% 增加到 72 小时后的 30.4%[4]。Zinc Protoporphyrin (1.25-40 μM；48 或 72 小时) 对肿瘤细胞产生抑囊/细胞毒性作用[4]。Zinc Protoporphyrin (2.5、5 μM；48 或 72 小时) 导致细胞周期 G1 期细胞的剂量和时间依赖性减少[4]。Zinc Protoporphyrin (1.25-40 μM；48 小时) 导致裂解 (活性) caspase-3 的积累[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Zinc Protoporphyrin-d2,15N2 相关抗体: |
| In Vivo | 原卟啉锌 (12.5、25、50 mg/kg 腹腔注射；12.5、50 mg/kg 口服；从第 7 天到第 19 天) 发挥剂量依赖性抗肿瘤作用，表现为延缓肿瘤生长[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C34H30D2N215N2O4Zn |
| Molar Mass | 630.02 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Park C, et al. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosisthrough Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes. Mar Drugs. 2019 Apr 13;17(4). [3]. Nowis D, et al. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice. BMC Cancer. 2008 Jul 11;8:197. [4]. Mwangi MN, et al. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women. BMC Med. 2014 Nov 26;12:229. |
Zinc Protoporphyrin-d2,15N2
CAS: F: C34H30D2N215N2O4Zn W: 630.02
Zinc Protoporphyrin-d2,15N2 is 15N and deuterated labeled Zinc Protoporphyrin (HY-101193). Zinc Protoporphyrin (Zn(II)-p
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