PeptideDB

Zidebactam

CAS: 1436861-97-0 F: C13H21N5O7S W: 391.40

Zidebactam (WCK-5107) is a potent β-lactamase inhibitor. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibi
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Bioactivity Zidebactam (WCK-5107) is a potent β-lactamase inhibitor[1]. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL[2].
Target IC50: 0.26 μg/mL (P. aeruginosa PAO1 PBP2)
Invitro Zidebactam (WCK-5107) inhibits WT Enterobacteriaceae with a MIC50 of 0.25 mg/L. Zidebactam alone exhibits variable activity when tested against E. coli (MIC50/90 0.12/0.12  mg/L) and Enterobacter spp. (MIC50/90 0.12/0.25  mg/L)[1].
Name Zidebactam
CAS 1436861-97-0
Formula C13H21N5O7S
Molar Mass 391.40
Appearance Solid
Transport Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Reference [1]. Sader HS, et al. WCK 5222 (cefepime/zidebactam) antimicrobial activity tested against Gram-negative organisms producing clinically relevant β-lactamases. J Antimicrob Chemother. 2017 Jun 1;72(6):1696-1703. [2]. Moya B, et al. WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent "β-Lactam Enhancer" Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-β-Lactamase-Producing High-Risk Clones. Antimicrob Agents Chem