| Bioactivity | Zaurategrast ethyl ester (CDP323), the ethyl ester prodrug of CT7758[1], is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders[2]. | ||||||||||||
| Target | α4β1/α4β7 integrin | ||||||||||||
| Invitro | Zaurategrast ethyl ester (CDP323), an ethyl ester prodrug of CT7758, shows some improvements in increasing mass transfer[1]. | ||||||||||||
| Name | Zaurategrast ethyl ester | ||||||||||||
| CAS | 455264-30-9 | ||||||||||||
| Formula | C28H29BrN4O3 | ||||||||||||
| Molar Mass | 549.46 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Chanteux H, et al. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist. Drug Metab Dispos. 2015 Sep;43(9):1381-91. [2]. Davenport RJ, et al. Alpha4-integrin antagonism--an effective approach for the treatment of inflammatory diseases? Drug Discov Today. 2007 Jul;12(13-14):569-76. |
Zaurategrast ethyl ester
CAS: 455264-30-9 F: C28H29BrN4O3 W: 549.46
Zaurategrast ethyl ester (CDP323), the ethyl ester prodrug of CT7758, is a α4β1/α4β7 integrin antagonist used for th
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