| Bioactivity | Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins. Zapalog dimerizes any two proteins tagged with the FKBP and DHFR domains until exposure to light causes its photolysis[1]. | ||||||||||||
| Target | FKBP, DHFR | ||||||||||||
| Name | Zapalog | ||||||||||||
| CAS | 1708091-24-0 | ||||||||||||
| Formula | C58H73N7O15 | ||||||||||||
| Molar Mass | 1108.24 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Gutnick A, et al. The light-sensitive dimerizer zapalog reveals distinct modes of immobilization for axonal mitochondria. Nat Cell Biol. 2019 Jun;21(6):768-777. |
Zapalog
CAS: 1708091-24-0 F: C58H73N7O15 W: 1108.24
Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously
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