ZM-306416 hydrochloride_product_DataBase

Bioactivity	ZM-306416 (CB-676475) hydrochloride is a potent VEGFR inhibitor with IC50s of 0.1 μM and 2 μM for KDR and Flt, respectively[1]. ZM-306416 is also a EGFR inhibitor with an IC50 of <10 nM[2].
Invitro	ZM-306416 对 EGFR 依赖的 NSCLC 细胞系 H3255 和 HCC4011 诱导选择性抗增殖作用（IC50 分别为 90 nM 和 72 nM），同时不影响野生型 EGFR 细胞系 A549 和 H2030（IC50 > 10 μM）[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> ZM-306416 hydrochloride 相关抗体:
CAS	196603-47-1
Formula	C16H14Cl2FN3O2
Molar Mass	370.21
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. L F Hennequin, et al. Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. J Med Chem. 1999 Dec 30;42(26):5369-89. [2]. Antczak C, Mahida JP, Bhinder B, A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery. J Biomol Screen. 2012 Aug;17(7):885-99.

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