| Bioactivity | ZM 253270 is a species-selective non-peptide NK-2 receptor (NK-2R) antagonist. ZM 253270 competitively inhibits the binding of [3H]NKA to native or cloned NK-2R from hamster bladder (Ki=2 nM), but has a weaker inhibitory effect (48-fold) on the binding of [3H]NKA to cloned human NK-2R[1]. |
| CAS | 169340-04-9 |
| Formula | C22H26ClN7O3 |
| Molar Mass | 471.94 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Aharony D, et al. Pharmacological characterization of a new class of nonpeptide neurokinin A antagonists that demonstrate species selectivity[J]. Journal of Pharmacology and Experimental Therapeutics, 1995, 274(3): 1216-1221. |