| Bioactivity | ZLWH-23 is a selective AChE inhibitor (IC50=0.27 μM) with GSK-3β inhibitory property (IC50=6.78 μM). ZLWH-23 possesses selectivity for AChE over BChE (IC50=20.82 μM) and for GSK-3β over multi-kinases. ZLWH-23 has the potential for the research of Alzheimer's disease[1]. |
| Invitro | ZLWH-23 exhibits good selectivity for GSK-3β over multi-kinases and very low cytotoxicity towards SH-SY5Y, HEK-293T, HL-7702, and HepG2 cell lines[1]. |
| In Vivo | ZLWH-23 displays efficient reduction against tau hyperphosphorylation on Ser-396 site in Tau (P301L) 293T cell model[1]. |
| Name | ZLWH-23 |
| CAS | 2765251-12-3 |
| Formula | C30H32FN5O2 |
| Molar Mass | 513.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liu W, et al. Discovery of novel β-carboline derivatives as selective AChE inhibitors with GSK-3β inhibitory property for the treatment of Alzheimer's disease. Eur J Med Chem. 2022;229:114095. |