ZK824190

CAS: 2254001-81-3 F: C22H20F2N2O4 W: 414.40

ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment f

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Bioactivity	ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively[1].
Target	IC50: 237 nM (uPA), 1600 nM (tPA), 1850 nM (Plasmin)
In Vivo	ZK824190 (2 mg/kg; PO) exhibits a relatively high oral availability and a moderate half time (T1/2=2.8 h)[1]. Animal Model:
Name	ZK824190
CAS	2254001-81-3
Formula	C22H20F2N2O4
Molar Mass	414.40
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Islam I, et al. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375.