| Bioactivity | ZIM, a norbornene derived from 4-Aminoantipyrine, is a potent inducer of DNA damage, causing genomic and chromosomal damage as well as inducing cell death and activating phagocytosis. ZIM has chemotherapeutic potential for use in cancer research[1]. | |||||||||
| In Vivo | ZIM (i.p., 12, 24 and 48 mg/kg)在成年雄性瑞士小鼠中，可以有效降低所有剂量在 24 和 72 小时的染色体微核频率，具有一定的化学预防作用，并且损伤降低的百分比范围为 38.36 至 83.26%[1]。ZIM (i.p., 12, 24 and 48 mg/kg)可以降低由 cisplatin-CIS 和 doxorubicin-DOX 诱导的肝脏细胞和肾脏细胞死亡频率。在 12、24和 48 mg/kg 的剂量浓度下，其中 CIS 组中肝脏的损伤降低百分比分别为 79.27、75.20 和 52.84%，DOX 组的损伤降低百分比分别为 62.06、59.44 和 77.80%。CIS 组的肾脏损伤减少百分比为 45.29、36.09 和 41.61%，DOX 为 28.00、21.41 和 30.82%[1]。 | |||||||||
| Name | ZIM | |||||||||
| CAS | 301298-87-3 | |||||||||
| Formula | C20H19N3O3 | |||||||||
| Molar Mass | 349.38 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Rodrigo Juliano Oliveira, et al. ZIM, a Norbornene Derived from 4-Aminoantipyrine, Induces DNA Damage and Cell Death but in Association Reduces the Effect of Commercial Chemotherapeutics. Chem Res Toxicol. 2022 Dec 22. |