| Bioactivity | ZG-2291 is a selective inhibitor targeting FIH (Factor Inhibiting HIF) with oral activity. By binding to FIH, ZG-2291 promotes a conformational flip of a catalytically important tyrosine, enabling selective inhibition of FIH without affecting other 2OG oxygenases in the JmjC subfamily. ZG-2291k enhances thermogenesis in ob/ob mice and improves obesity-related symptoms and metabolic dysfunctions. ZG-2291 holds promise for research in the field of obesity-related diseases[1]. |
| Invitro | ZG-2291 (5 或 20 μM，48 小时) 在 Hep3B 细胞中是一种具有活性的细胞穿透性 FIH 抑制剂[1]。ZG-2291 (5 或 20 μM，48 小时) 促进了 3T3-L1 衍生脂肪细胞中的产热作用并改善了脂质堆积[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> ZG-2291 相关抗体: Real Time qPCR[1] Cell Line: |
| In Vivo | ZG-2291 (10 mg/kg，腹腔注射，每隔一天一次，共 30 天) 可对抗 ob/ob 小鼠的肥胖症状，并显著改善其与肥胖相关的代谢功能障碍[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 2962103-40-6 |
| Formula | C17H12ClN3O5 |
| Molar Mass | 373.75 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wu Y, et al. A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-flip Pocket for the Treatment of Obesity. Angew Chem Int Ed Engl. 2024 Jun 26:e202410438. |
ZG-2291
CAS: 2962103-40-6 F: C17H12ClN3O5 W: 373.75
ZG-2291 is a selective inhibitor targeting FIH (Factor Inhibiting HIF) with oral activity. By binding to FIH, ZG-2291 pr
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