| Bioactivity | ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with Kis of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase, respectively. | ||||||||||||
| Target | Ki: 6.7 nM (Human neutrophil elastase), 200 nM (Human neutrophil elastase) | ||||||||||||
| In Vivo | ZD0892 administration to DBA/2 mice infected with the EMC virus results in reduced myocardial elastolytic activity and coronary microvascular perfusion injury. ZD0892 decreases the pathologic severity of the myocardial lesions associated with murine viral myocarditis[1]. ZD-0892 can reverse advanced pulmonary vascular disease produced in rats[2]. | ||||||||||||
| Name | ZD-0892 | ||||||||||||
| CAS | 171964-73-1 | ||||||||||||
| Formula | C24H32F3N3O5 | ||||||||||||
| Molar Mass | 499.52 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Lee JK, et al. A serine elastase inhibitor reduces inflammation and fibrosis and preserves cardiac function after experimentally-induced murine myocarditis. Nat Med. 1998 Dec;4(12):1383-91. [2]. Cowan KN, et al. Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor. Nat Med. 2000 Jun;6(6):698-702. |
ZD-0892
CAS: 171964-73-1 F: C24H32F3N3O5 W: 499.52
ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with Kis of 6.7 and 200 nM for human neutrophil ela
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