| Bioactivity | ZC0109 is a dual inhibitor of IDO1 and thioredoxin reductase 1 (TrxR1) with IC50s of 50 nM and 3.0 μM, respectively. ZC0109 induces ROS accumulation and cell cycle arrest at G1/S phase, thus leads to cancer cells apoptosis[1]. |
| Invitro | ZC0109 (24 h) inhibits cancer cells with IC50s of 3.44 μM (HCT-116), 12.4 μM (CT26), and 10.2 μM (HeLa), respectively[1].ZC0109 (2.5-10 μM; 24 h) induces ROS accumulation in HCT-116 and HeLa cells[1].ZC0109 (2.5-10 μM; 24 h) induces apoptosis and G1/S cell cycle arrest in cancer cell[1]. Cell Cycle Analysis[1] Cell Line: |
| Name | ZC0109 |
| Formula | C22H20BrFN8O4S |
| Molar Mass | 591.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |