| Bioactivity | Z433927330 is a potent and selective inhibitor of Aquaporin-7 (AQP7), less potently inhibits AQP3 and AQPs9, with IC50s of ~0.2 µM, ~0.7 µM and ~1.1 µM for mAQP7, mAQP3 and mAQP9, respectively[1]. | ||||||||||||
| Target | IC50: ~0.2 µM (mAQP7), ~0.7 µM (mAQP3), ~1.1 µM (mAQP9) | ||||||||||||
| Invitro | Z433927330 inhibits glycerol permeability, with an IC50 of ~0.6 µM[1]. | ||||||||||||
| Name | Z433927330 | ||||||||||||
| CAS | 1005883-72-6 | ||||||||||||
| Formula | C20H20N4O3 | ||||||||||||
| Molar Mass | 364.40 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Z433927330, et al. Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors. J Biol Chem. 2019 May 3;294(18):7377-7387. |
Z433927330
CAS: 1005883-72-6 F: C20H20N4O3 W: 364.40
Z433927330 is a potent and selective inhibitor of Aquaporin-7 (AQP7), less potently inhibits AQP3 and AQPs9, with IC50s
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