| Bioactivity | Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities[1]. | ||||||
| Invitro | Z-YVAD-FMK (100 μM; 24 hours) significantly downregulated the growth inhibition induced by butyrate in Caco-2 cells[1].Z-YVAD-FMK (20 μM; pre 1 hour; 24 hours) attenuates the apoptotic induction of III-10 on both HepG2 and BEL-7402 cells, the apoptotic rate of -10 on HepG2 cells is reduced by Z-VAD-FMK from 19.88% to 8.34%, while that on BEL-7402 cells is reduced from 17.56% to 11.98%[4]. Cell Viability Assay[1] Cell Line: | ||||||
| Name | Z-YVAD-FMK | ||||||
| CAS | 210344-97-1 | ||||||
| Sequence | Z-Tyr-Val-Ala-Asp-FMK | ||||||
| Shortening | Z-YVAD-FMK | ||||||
| Formula | C31H39FN4O9 | ||||||
| Molar Mass | 630.66 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |