Z-VRPR-FMK_product_DataBase

Bioactivity	Z-VRPR-FMK is an irreversible MALT1 protein inhibitor. Z-VRPR-FMK inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression[1].
Invitro	Z-VRPR-FMK(50 μM, 24 h)可以有效降低 HBL-1 细胞核 c-REL 水平，抑制了 NF-κB 的信号传导[2]。 Z-VRPR-FMK(50 μM, 48 h)对 ABC-DLBCL 细胞系 HBL-1, TMD8, OCI-Ly3 和 OCI-Ly10 具有一定的抑制增殖作用[2]。
Name	Z-VRPR-FMK
CAS	1381885-28-4
Formula	C31H49FN10O6
Molar Mass	676.78
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Jianglong Feng, et al. Z-VRPR-FMK can inhibit the growth and invasiveness of diffuse large B-cell lymphoma by depressing NF-κB activation and MMP expression induced by MALT1. Int J Clin Exp Pathol. 2019 Jun 1;12(6):1947-1955. [2]. Lorena Fontan, et al. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell. 2012 Dec 11;22(6):812-24.

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