Z-Pro-Pro-aldehyde-dimethyl acetal_product_DataBase

Bioactivity	Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease[1][2].
Name	Z-Pro-Pro-aldehyde-dimethyl acetal
CAS	170116-63-9
Sequence	Pro-{Pro-Aldehyde-dimethyl acetal}
Shortening	P-{Pro-Aldehyde-dimethyl acetal}
Formula	C20H28N2O5
Molar Mass	376.45
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Robin S B Williams, et al. A common mechanism of action for three mood-stabilizing drugs. Nature. 2002 May 16;417(6886):292-5. [2]. Andis Klegeris, et al. Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP‐1 cell neurotoxicity. Glia. 2008 Apr 15;56(6):675-85.

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