| Bioactivity | Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge[1][2]. |
| Target | cysteine protease. |
| Name | Z-Leu-Leu-Leu-fluoromethyl ketone |
| CAS | 371167-61-2 |
| Sequence | Z-Leu-Leu-Leu-FMK |
| Shortening | Z-LLL-FMK |
| Formula | C27H42FN3O5 |
| Molar Mass | 507.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Simmons G, et al. Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11876-81. [2]. Baig S, et al. Cysteine proteinase inhibitors in murine cysticercosis. Antimicrob Agents Chemother. 2006 Aug;50(8):2886-8. |
Z-Leu-Leu-Leu-fluoromethyl ketone
CAS: 371167-61-2 F: C27H42FN3O5 W: 507.64
Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibi
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