| Bioactivity | Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor. Z-LEVD-FMK blocks ER stress-induced apoptosis in cancer cells[1]. |
| Invitro | Z-LEVD-FMK (2 ng/mL, 30 min) blocks IL-1β-induced IL-8 production in hRPE cells[1].Z-LEVD-FMK (2 μM) inhibits caspase-3 activity in hRPE cells[1].Z-LEVD-FMK (20 μM, 96 h) completely blocks E2-induced PARP cleavage in 5C cells[2].Z-LEVD-FMK (20 μM, 96 h) reverses E2-inhibited growth and prevents morphologic alterations associated with apoptosis in 5C cells[2]. Western Blot Analysis[1] Cell Line: |
| Name | Z-LEVD-FMK |
| CAS | 1135688-25-3 |
| Formula | C31H45FN4O10 |
| Molar Mass | 652.71 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |