| Bioactivity | Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch[1][2]. | ||||||||||||
| Invitro | Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 in vitro polarization assays[1]. Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity[2]. RT-PCRsup>[1] Cell Line: | ||||||||||||
| Name | Z-Ile-Leu-aldehyde | ||||||||||||
| CAS | 161710-10-7 | ||||||||||||
| Formula | C20H30N2O4 | ||||||||||||
| Molar Mass | 362.46 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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