Z-335 sodium_product_DataBase

Bioactivity	Z-335 sodium is an orally active thromboxane a2 (TXA2) receptor antagonist, with IC50 values of 29.9 nM and 32.5 nM for human and Guinea pig platelets, respectively[1][2].
In Vivo	Z-335 (0.3-3 mg/kg, p.o.) 以剂量依赖的方式抑制血栓形。Z-335 (3 mg/kg, p.o.) 即使在 16 小时后也能显著防止血栓形成[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	146731-14-8
Formula	C18H17ClNNaO4S
Molar Mass	401.84
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. T Tanaka, et al. Antiplatelet effect of Z-335, a new orally active and long-lasting thromboxane receptor antagonist. Eur J Pharmacol. 1998 Sep 11;357(1):53-60. [2]. T Tanaka, et al. Z-335, a new thromboxane A(2) receptor antagonist, prevents arterial thrombosis induced by ferric chloride in rats. Eur J Pharmacol. 2000 Aug 11;401(3):413-8.

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