| Bioactivity | Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca2+ influx through voltage-gated Ca2+ channels, leading to the reduction in [Ca2+]i in vascular smooth muscle cells and consequent peripheral vasodilation[1]. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC50 of 33.8 μM and for anti-inflammatory activity with an IC50 of 37.4 μM[2]. |
| Name | Yangambin |
| CAS | 13060-14-5 |
| Formula | C24H30O8 |
| Molar Mass | 446.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
Yangambin
CAS: 13060-14-5 F: C24H30O8 W: 446.49
Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including specie
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