| Bioactivity | YX968 is a potent and selective HDAC3/8 dual degrader with DC50 values of 1.7 and 6.8 nM. YX968 exhibits antitumor activity by promoting apoptosis[1]. |
| Invitro | YX968 (1 μM, 24 h) 可通过阻滞细胞 G1 期诱导细胞凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> YX968 相关抗体: Western Blot Analysis[1] Cell Line: |
| CAS | 2742732-92-7 |
| Formula | C45H66N8O5S |
| Molar Mass | 831.12 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xiao Y, et al. HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation. Cell Chem Biol. 2023 Nov 16;30(11):1421-1435.e12. |