| Bioactivity | YPLP is a yeast-derived peptide Tyr-Pro-Leu-Pro, which exhibits activity in anti fatigue mechanisms through the nuclear factor erythroid-2-related factor 2 (Nrf2)- and AMP-activated protein kinase (AMPK) pathway. YPLP is orally active[1]. |
| In Vivo | YPLP (10-50 mg/kg，灌胃，共四周) 通过 Nrf2/Keap1 通路减少脂质氧化并增加肌肉组织中的抗氧化酶活性，从而减轻 ICR 小鼠体内由运动引起的氧化损伤[1]。YPLP (10-50 mg/kg，灌胃，共四周) 通过 AMPK 磷酸化和提高 AMPK 蛋白水平改善疲劳 ICR 小鼠的 ATP 水平和能量代谢[1]。YPLP (10-50 mg/kg，灌胃，共四周) 调节差异丰度蛋白 (DAP) 的表达，参与蛋白质合成/降解、肌肉动力学和核转运过程，从而调节疲劳小鼠的肌肉功能[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 2414391-44-7 |
| Sequence | Tyr-Pro-Leu-Pro |
| Shortening | YPLP |
| Formula | C25H36N4O6 |
| Molar Mass | 488.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cai J, et al., Studying Antifatigue Mechanism of Tyr-Pro-Leu-Pro in Exercise Mice Using Label-Free Proteomics. J Agric Food Chem. 2024 Jan 31;72(4):2178-2192. |