| Bioactivity | YL-939 is a potent ferroptosis inhibitor. YL-939 inhibits ferroptosis by targeting the PHB2/ferritin/iron axis[1]. | |||||||||
| Invitro | YL-939 (0.01-10 μM) 有效保护细胞免于铁死亡，对 HT-1080, Miapaca-2, Calu-1, HCT116 和 SHSY5Y 细胞的 IC50 值为 0.14 μM、0.25 μM、0.16 μM、0.16 μM 和 0.24 μM[1].YL-939 (5 μM；10 小时；ES-2 细胞) 降低细胞溶质、膜脂中的 ROS 水平[1]。YL-939 (5 μM；1-10 h；ES-2 细胞) 具有 PHB2 生物学靶标[1]。YL-939 (3 μM；10 h；ES-2 细胞) 以浓度依赖性方式改善铁蛋白表达并阻断自噬体/溶酶体，从而抑制铁蛋白自噬[1]。 Western Blot Analysis[1] Cell Line: | |||||||||
| In Vivo | YL-939 (3 mg/kg；腹腔注射；单次注射) 改善 对乙酰氨基酚 (APAP) 中的肝损伤-诱导的急性肝损伤模型[1]. Animal Model: | |||||||||
| Name | YL-939 | |||||||||
| Formula | C25H26N6O | |||||||||
| Molar Mass | 426.51 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Yang W, et, al. Non-classical ferroptosis inhibition by a small molecule targeting PHB2. Nat Commun. 2022 Dec 3;13(1):7473. |