| Bioactivity | YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM for SIK1, SIK2 and SIK3, respectively[1]. | ||||||||||||
| Invitro | YKL 06-062 (0.0004-16 μM; 3 hours) increases MITF mRNA expression in a dose-dependent manner[1]. RT-PCR[1] Cell Line: | ||||||||||||
| Name | YKL-06-062 | ||||||||||||
| CAS | 2172617-16-0 | ||||||||||||
| Formula | C31H39N7O | ||||||||||||
| Molar Mass | 525.69 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Mujahid N, et al. A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin. Cell Rep. 2017 Jun 13;19(11):2177-2184. |
YKL-06-062
CAS: 2172617-16-0 F: C31H39N7O W: 525.69
YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM for SIK1
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