| Bioactivity | YK-4-279 blocks RNA Helicase A (RHA) binding with EWS-FLI1 (oncogenic protein). YK-4-279 induces apoptosis and shows anti-proliferation activities towards various cancer cells. YK-4-279 has a chiral center and it can be separated into two enantiomers. YK-4-279 can be used for the research of cancer[1][2]. | ||||||||||||
| Invitro | YK-4-279 (3-30 µM; overight) dissociates EWS-FLI1 from RHA in Ewing’s sarcoma family tumor (ESFT) cells[1].YK-4-279 (3-30 µM; 14 h) nearly eliminates cyclin D1 in TC32 cells[1].YK-4-279 (3-30 µM; 72 h) potently and specifically inhibits ESFTs[1].YK-4-279 (50 µM; 6 h) induces substantial apoptosis of ESFT cells[1].YK-4-279 (0.1-30 µM; 72 h) inhibits the growth of ESFT, prostate, breast and pancreatic cancer cells[2]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | YK-4-279 | ||||||||||||
| CAS | 1037184-44-3 | ||||||||||||
| Formula | C17H13Cl2NO4 | ||||||||||||
| Molar Mass | 366.20 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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YK-4-279
CAS: 1037184-44-3 F: C17H13Cl2NO4 W: 366.20
YK-4-279 blocks RNA Helicase A (RHA) binding with EWS-FLI1 (oncogenic protein). YK-4-279 induces apoptosis and shows ant
Data collection：peptidedb@qq.com
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