| Bioactivity | YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent.IC50 value:Target: MDM2/p53YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion). | ||||||||||||
| Name | YH239-EE | ||||||||||||
| CAS | 1364488-67-4 | ||||||||||||
| Formula | C25H27Cl2N3O4 | ||||||||||||
| Molar Mass | 504.41 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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YH239-EE
CAS: 1364488-67-4 F: C25H27Cl2N3O4 W: 504.41
YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-induci
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