| Bioactivity | YG1702 is a potent ALDH18A1-specific inhibitor. YG1702 attenuates the growth of MYCN-amplified NB and down-regulates MYCN. YG1702 physically interacts with ALDH18A1 with a high affinity and might potentially affect its enzymatic activity[1]. |
| In Vivo | YG1702（腹腔注射，45 mg/kg，每3天一次，共3次）抑制荷瘤小鼠异种移植物的生长[1]。 Animal Model: |
| Name | YG1702 |
| CAS | 724737-08-0 |
| Formula | C23H30N2O7S |
| Molar Mass | 478.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Guo YF, et al. Inhibition of the ALDH18A1-MYCN positive feedback loop attenuates MYCN-amplified neuroblastoma growth. Sci Transl Med. 2020 Feb 19;12(531):eaax8694. |