| Bioactivity | YD54 is a PROTAC based SMARCA2 degrader with a DC50 of 3.5nM (Red: SMARCA2 degrader (HY-44012B), black: linker, Blue: E3 ligase ligand)[1]. |
| CAS | 2951015-30-6 |
| Formula | C40H42FN9O6 |
| Molar Mass | 763.82 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kotagiri S, et al. Discovery of Novel, Potent and Orally Bioavailable SMARCA2 PROTACs with Synergistic Anti-tumor Activity in Combination with KRAS G12C Inhibitors. bioRxiv [Preprint]. 2024 Aug 26:2024.08.23.608456. |