| Bioactivity | YAP/TAZ-TEAD-IN-2 (Compound 51) is a YAP/TAZ-TEAD inhibitor that inhibits the interaction between YAP/TAZ and TEAD. YAP/TAZ-TEAD-IN-2 suppresses the transcriptional activity of TEAD, with an IC50 of 1.2 nM. YAP/TAZ-TEAD-IN-2 inhibits YAP/TAZ-TEAD target genes expression (Cyr61, CTGF, AXL and Survivin) and breast cancer cell proliferation[1]. |
| Invitro | YAP/TAZ-TEAD-IN-2 (2.5-20 μM, 72 h) 剂量依赖性抑制 MDA-MB-231 细胞增殖，其 IC50 为 4.4 μM[1]。YAP/TAZ-TEAD-IN-2 (1-10 μM, 48 h) 抑制 MDA-MB-231 细胞中四种主要 YAP/TAZ-TEAD 靶蛋白，即 Cyr61、CTGF、AXL 和 BIRC5 (Survivin) 表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> YAP/TAZ-TEAD-IN-2 相关抗体: Cell Proliferation Assay[1] Cell Line: |
| Formula | C19H20N2O3S |
| Molar Mass | 356.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Toulotte, et al. Towards the design of ligands of the internal pocket TEADs C-terminal domain. European journal of medicinal chemistry, 2025, 282, 117026. |