| Bioactivity | Y-33075 hydrochloride (Y-39983) is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM. |
| Invitro | Y-33075 hydrochloride (Y-39983, 10 μM) 与未经Y-39983 处理的 RGCs 相比，延长了视网膜神经节细胞 (RGCs) 的神经突[2]。Y-33075 hydrochloride (Y-39983, 1 μM) 抑制组胺在Ca2+无溶液中引起的兔纤毛动脉段收缩。Y-33075 hydrochloride (10 μM) 对 Ca2+ 没有影响，随着高钾 (高 k) 溶液的加入而增加[3]。 |
| Name | Y-33075 hydrochloride |
| CAS | 471843-75-1 |
| Formula | C16H17ClN4O |
| Molar Mass | 316.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tokushige H, et al. Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats. Curr Eye Res. 2011 Oct;36(10):964-70. [2]. Watabe H, et al. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.Jpn J Ophthalmol. 2011 Jul;55(4):411-7. Epub 2011 Jun 11. |
Y-33075 hydrochloride
CAS: 471843-75-1 F: C16H17ClN4O W: 316.79
Y-33075 hydrochloride (Y-39983) is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632
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