Y-27632 dihydrochloride (GMP)

CAS: 129830-38-2 F: C14H23Cl2N3O W: 320.26

Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce

Contact QiTai

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce Y-27632 dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect[1][2][3][4].
Invitro	Y-27632 dihydrochloride (GMP) (2 μM; 4-8 d) 可提高直接转化为神经元细胞的小鼠成纤维细胞的存活率并增加重编程[1]。Y-27632 dihydrochloride (GMP) 诱导人成纤维细胞转化为功能性心肌细胞[2]。Y-27632 dihydrochloride (GMP) 诱导成纤维细胞转化为多能干细胞（hiPSCs）[2]。Y-27632 dihydrochloride (GMP) (2-10 μM) 促进人 EPS 细胞增殖并诱导 primed hPSCs 转化为 hEPS 细胞[3]。Y-27632 dihydrochloride (GMP) (10 μM) 诱导从囊胚衍生的人 EPS 细胞[4]。
Name	Y-27632 dihydrochloride (GMP)
CAS	129830-38-2
Formula	C14H23Cl2N3O
Molar Mass	320.26
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Reference	[1]. Li X, et al. Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. Cell Stem Cell. 2015 Aug 6;17(2):195-203. [2]. Cao N, et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016 Jun 3;352(6290):1216-20. [3]. Choi IY, et al. Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model. Cell Rep. 2016 Jun 7;15(10):2301-2312. [4]. Yang Y, et al. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017 Apr 6;169(2):243-257.e25.

Tetrabenazine-d6