| Bioactivity | Xylazine (BAY 1470) is a strong α2-adrenergic agonist whose effects are mediated via stimulation of central α2-receptors. Xylazine hydrochloride is used as a sedative, analgesic and muscle relaxant in veterinary medicine[1]. |
| In Vivo | Xylazine (5.2 mg/kg; intraperitoneal injection; for 10-60 minutes; male Sprague-Dawley rats) administration alters mRNA expression and protein phosphorylation levels of AMPK signaling molecules, suggesting that the LKB1-AMPK pathway plays a role in the sedative and tranquilizing effects in the CNS caused by Xylazine treatment[1]. Animal Model: |
| Name | Xylazine |
| CAS | 7361-61-7 |
| Formula | C12H16N2S |
| Molar Mass | 220.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shi XX, et al. Xylazine Activates Adenosine Monophosphate-Activated Protein Kinase Pathway in the CentralNervous System of Rats. PLoS One. 2016 Apr 6;11(4):e0153169. |