Xylazine-d6

CAS: 1228182-53-3 F: C12H10D6N2S W: 226.37

Xylazine-d6 is a deuterated labeled Xylazine. Xylazine (BAY 1470) is a strong α2-adrenergic agonist whose effects are m

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Bioactivity	Xylazine-d6 is a deuterated labeled Xylazine[1]. Xylazine (BAY 1470) is a strong α2-adrenergic agonist whose effects are mediated via stimulation of central α2-receptors. Xylazine hydrochloride is used as a sedative, analgesic and muscle relaxant in veterinary medicine[2].
Invitro	氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Xylazine-d6 相关抗体:
In Vivo	Xylazine (5.2 mg/kg; intraperitoneal injection; for 10-60 minutes; male Sprague-Dawley rats) administration alters mRNA expression and protein phosphorylation levels of AMPK signaling molecules, suggesting that the LKB1-AMPK pathway plays a role in the sedative and tranquilizing effects in the CNS caused by Xylazine treatment[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	1228182-53-3
Formula	C12H10D6N2S
Molar Mass	226.37
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Shi XX, et al. Xylazine Activates Adenosine Monophosphate-Activated Protein Kinase Pathway in the CentralNervous System of Rats. PLoS One. 2016 Apr 6;11(4):e0153169.