| Bioactivity | Xeruborbactam (QPX7728) is a potent, ultra-broad-spectrum boronic acid beta-lactamase inhibitor. Xeruborbactam inhibits key serine and metallo beta-lactamases at a nano molar range[1]. |
| Target | Beta-lactamase |
| Invitro | Xeruborbactam is a potent inhibitor of Class D carbapenemases from A. baumannii[1].Xeruborbactam is minimally affected by the activity of major MDR efflux pumps from P. aeruginosa, representing a significant improvement over the earlier generation boronate beta-lactamase inhibitor (BLI) vaborbactam[1]. The ultra-broad-spectrum beta-lactamase inhibition profile combined with enhancement of the activity of multiple beta-lactam antibiotics with varying sensitivity to the intrinsic resistance mechanisms of efflux and permeability indicate Xeruborbactam is a useful inhibitor for use with multiple beta-lactam antibiotics[1]. |
| Name | Xeruborbactam |
| CAS | 2170834-63-4 |
| Formula | C10H8BFO4 |
| Molar Mass | 221.98 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lomovskaya O, et al, The Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultra-Broad-Spectrum Beta-lactamase Inhibitor of Serine and Metallo Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii. |
Xeruborbactam
CAS: 2170834-63-4 F: C10H8BFO4 W: 221.98
Xeruborbactam (QPX7728) is a potent, ultra-broad-spectrum boronic acid beta-lactamase inhibitor. Xeruborbactam inhibits
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