| Bioactivity | Xanthine oxidase is a xanthine oxidoreductase enzyme that generates reactive oxygen species (ROS), catalyzes the oxidation of hypoxanthine to xanthine, and further catalyzes the oxidation of xanthine to uric acid[1]. |
| Invitro | Xanthine oxidase rapidly and completely depletes hypoxanthine in human erythrocytes[2].Xanthine oxidase (20 mU/mL, 72 h) inhibits growth of Plasmodium falciparum in human erythrocytes[2].Xanthine oxidase (0.02 U/mL, 6 h) reduces the viability of postnatal cerebellar granule neurons obtained from 8-day old Sprague-Dawley rat pups[3]. |
| Name | Xanthine oxidase |
| CAS | 9002-17-9 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. AdeebShehzad, et al. Chapter Eight - Curcumin: A Potent Modulator of Multiple Enzymes in Multiple Cancers. [2]. Berman PA, et al. Xanthine oxidase inhibits growth of Plasmodium falciparum in human erythrocytes in vitro. J Clin Invest. 1991 Dec;88(6):1848-55. [3]. Fatokun AA, et al. Hydrogen peroxide mediates damage by xanthine and xanthine oxidase in cerebellar granule neuronal cultures. Neurosci Lett. 2007 Apr 6;416(1):34-8. |