| Bioactivity | XS-060 is a potent anticancer agent and RXRα antagonist. XS-060 significantly induces RXRα-dependent mitotic arrest by inhibiting pRXRα-PLK1 interaction[1]. |
| Target | RXRα (Retinoid X receptor alpha) |
| Invitro | XS-060 靶向 RXRα' 的共激活因子结合位点可抑制 pRXRα-PLK1 相互作用，作为抗有丝分裂剂表现出良好的抗肿瘤活性[1]。XS-060 对 MDA-MB 231 癌细胞具有抗增殖活性，IC50 为 6.880 ± 0.059 μM[1]。 Cell Proliferation Assay[1] Cell Line: |
| In Vivo | XS-060 (25 mg/kg, IP or PO, once) 腹腔注射吸收良好，但口服吸收很差[1]。 Animal Model: |
| Name | XS-060 |
| CAS | 2787626-06-4 |
| Formula | C20H18N2O3 |
| Molar Mass | 334.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen J, et al. Discovery of bipyridine amide derivatives targeting pRXRα-PLK1 interaction for anticancer therapy. Eur J Med Chem. 2023 Apr 6;254:115341. |