| Bioactivity | XPO1-IN-1 (compound D4) is an orally active and potent XPO1 inhibitor, with an IC50 of 24 nM in MM.1S cell. XPO1-IN-1 can efficiently induce cell apoptosis and cell cycle arrest. XPO1-IN-1 displays favorable metabolic stability and pharmacokinetic properties. XPO1-IN-1 can be used for multiple myeloma (MM) research[1]. |
| Invitro | XPO1-IN-1 (compound D4) (24 h) shows high anti-proliferation efficacy in MM.1S cell and lymphomatous cell lines[1].XPO1-IN-1 (0-10 μM, 24 h) induces cancer cell cycle arrest[1].XPO1-IN-1 (0-10 μM, 48 h) induces apoptosis of MM.1S cell[1].XPO1-IN-1 (0-10 μM, 2 h) inhibits XPO1-dependent nuclear export[1].XPO1-IN-1 shows the good metabolic stability, with more than 80% intact compound remained over rat plasma (2 h), and around 85% intact compound remained in liver microsomes (1 h)[1]. Cell Proliferation Assay Cell Line: |
| Name | XPO1-IN-1 |
| Formula | C20H15F6N5O3S |
| Molar Mass | 519.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |