PeptideDB

XPC-6444

CAS: 2230144-21-3 F: C22H25F3N4O2S2 W: 498.58

XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1.6 inhibitor (IC50=41 nM for hNaV1.6). XPC-6444 al
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Bioactivity XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1.6 inhibitor (IC50=41 nM for hNaV1.6). XPC-6444 also displays potent block of NaV1.2 (IC50=125 nM). XPC-6444 shows anticonvulsant activity[1].
Target IC50: 41 nM (hNaV1.6), 125 nM (hNaV1.2)
Invitro XPC-6444 shows high selectivity over NaV1.1 and NaV1.5[1].
In Vivo XPC-6444 exhibits good metabolic stability in human liver microsomes and hepatocytes, and low potential for MDR1 mediated efflux[1].
Name XPC-6444
CAS 2230144-21-3
Formula C22H25F3N4O2S2
Molar Mass 498.58
Appearance Solid
Transport Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Reference [1]. Focken T, et al. Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy. J Med Chem. 2019 Oct 3.