| Bioactivity | XM462 is a dihydroceramide desaturase inhibitor. XM462 produced a mixed-type inhibition (Ki=2 μM) in vitro. XM462 has dihydroceramide desaturase inhibition both in vitro and in cultured cells with IC50 values of 8.2 and 0.78 μM, respectively. XM462 can be used for the research of tumor[1][2]. |
| Target | IC50: 8.2 μM (dihydroceramide desaturase in vitro); 0.78 μM (dihydroceramide desaturase in cultured cells). |
| Name | XM462 |
| CAS | 1045857-53-1 |
| Formula | C25H51NO3S |
| Molar Mass | 445.74 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Munoz-Olaya JM, et al. Synthesis and biological activity of a novel inhibitor of dihydroceramide desaturase. ChemMedChem. 2008 Jun;3(6):946-53. [2]. Camacho L, et al. 3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate. Bioorg Med Chem. 2012 May 15;20(10):3173-9. |