| Bioactivity | XL44, an hRpn13 binder, induces hRpn13-dependent apoptosis and also restricts cell viability by a PCLAF-dependent mechanism. XL44 induces ubiquitin-dependent loss of hRpn13Pru and ubiquitin-independent loss of select KEN box containing proteins[1]. |
| Invitro | XL44 (20 μM, 4-24 h, lysates from RPMI 8226 cells) induces apoptosis in an hRpn13-dependent manner and reduces hRpn13Pru levels[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> XL44 相关抗体: Western Blot Analysis[1]. Cell Line: |
| CAS | 2637949-91-6 |
| Formula | C23H17FN2O3 |
| Molar Mass | 388.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xiuxiu Lu, et al. A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins. Nat Commun. 2024 Mar 20;15(1):2485. |