| Bioactivity | XJTU-L453 is a PI3Kα inhibitor with an IC50 value of 0.4 nM. XJTU-L453 can inhibit the proliferation of breast cancer cell lines T47D and MCF7, with IC50 values of 0.2 μM and 0.5 μM, respectively. XJTU-L453 can inhibit the PI3K pathway, induce cell cycle arrest, and trigger cell apoptosis (apoptosis). XJTU-L453 also has antitumor activity in MCF7 xenograft mice[1]. |
| CAS | 3008290-92-1 |
| Formula | C22H22N4O3 |
| Molar Mass | 390.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shi X, et al. Rational Design of a Novel 6H-Benzo[c]chromen Series as Selective PI3Kα Inhibitors. J Med Chem. 2024 Aug 19. |
XJTU-L453
CAS: 3008290-92-1 F: C22H22N4O3 W: 390.44
XJTU-L453 is a PI3Kα inhibitor with an IC50 value of 0.4 nM. XJTU-L453 can inhibit the proliferation of breast cancer c
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