| Bioactivity | X5050 is a REST inhibitor, with an EC50 of 2.1 μM[1]. | ||||||||||||
| Invitro | X5050 (100 µM, 1 day) induces a dosedependent decrease in the REST isoform in protein level[1]. Western Blot Analysis[1] Cell Line: | ||||||||||||
| In Vivo | X5050 (2 x 2µl of 20 mM) is active in HD pathological context[1]. Animal Model: | ||||||||||||
| Name | X5050 | ||||||||||||
| CAS | 2404756-81-4 | ||||||||||||
| Formula | C17H15N3O3 | ||||||||||||
| Molar Mass | 309.32 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Jérémie Charbord, et al. High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes. Stem Cells. 2013 Sep;31(9):1816-28. |