| Bioactivity | Wu-5 is a USP10 inhibitor that can inhibit FLT3 and AMPK pathways, induce FLT3-ITD degradation and induce apoptosis[1]. |
| Invitro | Wu-5 (10 μM; 24, 48, 72 h) 选择性诱导 FLT3-ITD 阳性 AML 细胞死亡[1]。Wu-5 (1, 2.5, 5 μM; 24, 48 h) 以时间和浓度依赖的方式诱导 FLT3-ITD 阳性 AML 细胞凋亡[1]。Wu-5 (5 μM; 24 h) 通过蛋白酶途径诱导 FLT3-ITD 降解[1]。 0 --> Wu-5 相关抗体: Cell Viability Assay[1] Cell Line: |
| Name | Wu-5 |
| CAS | 2630378-05-9 |
| Formula | C15H13NO7S |
| Molar Mass | 351.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Miao Yu, et al. Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways. Acta Pharmacol Sin. 2021 Apr;42(4):604-612. |