| Bioactivity | Wortmannin (SL-2052; KY-12420) is a potent, selective and irreversible PI3K inhibitor with an IC50 of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC50s of 5.8 and 48 nM, respectively[1][2][3]. | ||||||||||||
| Invitro | Wortmannin (0-100 nM; 24-72 hours) inhibits the proliferation of K562 cells in a time- and dose-dependent manner. The IC50 values at 24 hour, 48 hour, and 72 hour are 25±0.10 nM, 12.5±0.08 nM, and 6.25±0.11 nM, respectively[4].Wortmannin prevents nuclear entry of YAP[6]. Cell Proliferation Assay[4] Cell Line: | ||||||||||||
| Name | Wortmannin | ||||||||||||
| CAS | 19545-26-7 | ||||||||||||
| Formula | C23H24O8 | ||||||||||||
| Molar Mass | 428.43 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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