Wnt/β-catenin-IN-3_product_DataBase

Bioactivity	Wnt/β-catenin-IN-3 (compound 17) is a Wnt/β-catenin inhibitor with low micromolarGI50s against various cancer cells. Wnt/β-catenin-IN-3triggers G2/M cell cycle arrest though activation of p53-p21 pathway as well as intrinsic and extrinsic apoptotic death of colon cancer cells[1].
Invitro	Wnt/β-catenin-IN-3 (0.5-2 μM, 48 h) 剂量依赖性地诱导 HCT116 细胞凋亡，并通过激活 p53-p21 通路导致 G2/M 细胞周期阻滞[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Wnt/β-catenin-IN-3 相关抗体:
CAS	1809413-98-6
Formula	C26H23NO7
Molar Mass	461.46
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hassan AHE, et al. Discovery of a stilbenoid-flavanone hybrid as an antitumor Wnt/β-catenin signaling pathway inhibitor. Bioorg Chem. 2024 Apr;145:107178.

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