| Bioactivity | Wnt/β-catenin-IN-2 (Compound 3235-0367) is a Wnt/β-catenin signaling pathway inhibitor, with IC50 and KD values of 7.1 and 2.5 μM, respectively. Wnt/β-catenin-IN-2 can be used for the research of cancer[1]. |
| Invitro | Wnt/β-catenin-IN-2 (0-40 μM，12-16 h) 在 Wnt3a 处理的 3T3 细胞中，以剂量依赖性方式以低微摩尔范围抑制 Wnt3a 诱导的 β 信号传导[1]。Wnt/β-catenin-IN-2 (10 μM, 3 h) 抑制 Wnt3a 处理 HEK293T 细胞中 Wnt 信号传导诱导的 LRP6 磷酸化[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Wnt/β-catenin-IN-2 相关抗体: |
| CAS | 1397006-01-7 |
| Formula | C28H30N4O6 |
| Molar Mass | 518.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lee HJ, et al. Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled. J Biol Chem. 2015 Dec 18;290(51):30596-606. |
Wnt/β-catenin-IN-2
CAS: 1397006-01-7 F: C28H30N4O6 W: 518.56
Wnt/β-catenin-IN-2 (Compound 3235-0367) is a Wnt/β-catenin signaling pathway inhibitor, with IC50 and KD values of 7.1
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