Werner syndrome RecQ helicase-IN-4_product_DataBase

Bioactivity	Werner syndrome RecQ helicase-IN-4 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 µM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity[1].
Target	IC50: 0.06 µM (WRN)
Invitro	Werner syndrome RecQ helicase-IN-4 (example 58) (0-10 µM; 8-20 days) 显示抗增殖活性，对 SW48，DLD1 WRN-KO 细胞的 GI50s 值分别为 0.07，>10 µM[1]。 Cell Proliferation Assay[1] Cell Line:
In Vivo	Werner syndrome RecQ helicase-IN-4 (240 mg/kg; daily for 18 days) 在小鼠体内显示出抗癌活性[1]。 Animal Model:
Name	Werner syndrome RecQ helicase-IN-4
CAS	2869954-53-8
Formula	C32H33F3N8O5
Molar Mass	666.65
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Vincent Bordas, et al. Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of werner syndrome recq helicase (wrn). WO2022249060A1.

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